Phaeohyphomycosis is a chronic infectious disease caused by dematiaceous fungi. It is characterized by the presence of pigmented septate mycelia within tissues. In the case of superficial infection, the lesion(s) chronically evolve(s) toward painless pseudo-tumor(s) of the soft parts. We report herein the original case of a heart transplanted man who exhibited phaeohyphomycosis of the left hand, with no mention of travels in endemic areas. Trematosphaeria grisea was identified as the causative agent, which is quite innovative since this species has been rather described in mycetoma. The antifungal treatment initially based on isavuconazole alone was not sufficient to cure the patient. In contrast, its association with local terbinafine ointment allowed total clinical improvement. This finding is unusual as diagnosis of phaeohyphomycosis caused by T. grisea is uncommon in nontropical countries, and as the outcome appeared successful by the means of add-on therapeutic strategy with terbinafine.

褐丝菌病是一种由暗色真菌引起的慢性传染病。它的特征在于组织内存在有色隔膜菌丝体。在浅表感染的情况下，病变长期发展为软部的无痛假瘤。我们在此报告了一名心脏移植男子的原始病例，该男子表现出左手嗜铬丝孢菌病，但没有提及到流行地区的旅行。灰吸球虫被确定为病原体，这是非常创新的，因为该物种已在足菌肿中得到了相当的描述。最初仅基于艾沙康唑的抗真菌治疗不足以治愈患者。相比之下，它与局部特比萘芬软膏的结合使临床总体改善。这一发现是不寻常的，因为由T. grisea引起的褐丝菌病的诊断在非热带国家并不常见，而且通过使用特比萘芬的附加治疗策略，结果似乎很成功。