New magnetic molecularly imprinted polyurethanes based on magnetic multi-walled carbon nanotubes (MMWNTs-MIPUs) were synthesized with specific selectivity toward ketoconazole (KTZ) as an anti-fungal drug. First, novel N-(4-carboxyphenyl) trimellitimide diisocyanate (NTDIS) was prepared from the reaction of trimellitic anhydride and 4-amino benzoic acid in two steps. Then, NTDIS was functionalized by β-cyclodextrin and methacrylic acid (MAA-NTDIS-β-CD). MAA-NTDIS-β-CD was used as a functional monomer, KTZ as a template, ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent and 2,2′-azobisisobutyronitrile (AIBN) as initiator. Structure and properties of the prepared compounds were characterized by FTIR, ¹H NMR, FESEM, XRD, VSM, BET, and EDX. The influence of parameters such as solution pH, contact time, temperature, and initial concentrations in controlled absorption of KTZ using MMWCNTs-MIPU and MMWCNTs-NIPU were evaluated. The kinetic data were measured using the pseudo-first-order and pseudo-second-order equation. The pseudo-second-order equation displayed the best fit for the kinetic studies (R² 0.9958). The adsorption equilibrium of KTZ using MMWCNTs-MIPU could be well-defined with the Langmuir isotherm model, and the maximum adsorption capacity was calculated as 52.35 mg g^–1. The prepared MMWCNTs-MIPU can be simply separated by an external magnetic field and, MMWCNTs-MIPU can be used after six filtration-regeneration cycles.

中文翻译：

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使用新型分子印迹聚氨酯涂层磁性多壁碳纳米管从水溶液中选择性吸附酮康唑

合成了基于磁性多壁碳纳米管（MMWNTs-MIPUs）的新型磁性分子印迹聚氨酯，该化合物对酮康唑（KTZ）有抗真菌药的选择性。首先，通过偏苯三酸酐与4-氨基苯甲酸的两步反应制备了新型的N-（4-羧基苯基）偏苯三甲酰亚胺二异氰酸酯（NTDIS）。然后，将NTDIS通过β-环糊精和甲基丙烯酸（MAA-NTDIS-β-CD）进行官能化。使用MAA-NTDIS-β-CD作为功能单体，使用KTZ作为模板，使用乙二醇二甲基丙烯酸酯（EGDMA）作为交联剂，并使用2,2'-偶氮二异丁腈（AIBN）作为引发剂。FTIR表征了所制备化合物的结构和性质，¹1 H NMR，FESEM，XRD，VSM，BET和EDX。使用MMWCNTs-MIPU和MMWCNTs-NIPU评估了溶液pH，接触时间，温度和初始浓度等参数对KTZ吸收控制的影响。使用伪一阶和伪二阶方程测量动力学数据。拟二阶方程组最适合动力学研究（R ² 0.9958）。使用MMWCNTs-MIPU可以用Langmuir等温线模型很好地定义KTZ的吸附平衡，最大吸附容量经计算为52.35 mg g ^–1。所制备的MMWCNTs-MIPU可以通过外部磁场简单地分离，并且MMWCNTs-MIPU可以在六个过滤再生循环后使用。