Hyperlipidemia is involved in serious cardiovascular disease, however, synthetic drugs to reduce lipid contents in blood stream have been found to induce serious side effects. In the current study, we compared anti-oxidant and anti-hyperlipidemic effect of Paecilomyces japonica (PJ), Cordyceps militaris (CM) and cordycepin-rich Cordyceps militaris (CMα) in rats induced alcoholic hyperlipidemia (AIH) and oxidative stress. The experimental groups were divided in N (water), C (30% alcohol), PJ (30% alcohol + 3% PJ powder), CM (30% alcohol + 3% CM powder), CMα (30% alcohol + 3% CMα powder) and SM [30% alcohol + 0.1% silymarin (SM)]. Compared to C group, supplementation of PJ, CM, CMα and SM slightly alleviated the increased weight ratio of liver and kidney in the alcohol-treated rats. In addition, a significant or slight reduction was identified in total lipid, total cholesterol and HDL-cholesterol levels in the rats receiving PJ, CM and CMα as compared with C group. Administration of PJ, CM and CMα also blocked alcohol-induced lipid peroxidation via a decrease of malondialdehyde (MDA), and activated anti-oxidant enzyme, glutathione (GSH), in serum and various organ tissues. Overall, cordycepin-rich CMα showed highest anti-oxidant and anti-hyperlipidemia effect under chronic alcoholic damage. Our results indicate that CMα might be useful in inhibiting the oxidation and hyperlipidemia in alcohol-induced hepatic disease possibly because of potential anti-oxidative and anti-hyperlipidemic activities of cordycepin.

中文翻译：

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富含虫草素的Cord虫草在酒精诱发的高脂血症和氧化应激的Sprague-Dawley大鼠模型中的抗氧化和抗高血脂作用

高脂血症与严重的心血管疾病有关，但是，已经发现减少血液中脂质含量的合成药物会引起严重的副作用。在本研究中，我们比较了日本拟青霉（Pajcilomyces japonica），mil虫草（虫草）和富含虫草素的Cord虫草（Cordyceps militaris）的抗氧化和抗高血脂作用（CMα）在大鼠中诱发酒精性高脂血症（AIH）和氧化应激。实验组分为N（水），C（30％酒精），PJ（30％酒精+ 3％PJ粉），CM（30％酒精+ 3％CM粉），CMα（30％酒精+ 3％） CMα粉末）和SM [30％酒精+ 0.1％水飞蓟素（SM）]。与C组相比，补充PJ，CM，CMα和SM可以稍微减轻酒精治疗大鼠的肝肾重量比。此外，与C组相比，在接受PJ，CM和CMα的大鼠中，总脂质，总胆固醇和HDL-胆固醇水平明显降低或略有降低。施用PJ，CM和CMα还可以通过降低血清和各种器官组织中的丙二醛（MDA）和活化的抗氧化酶谷胱甘肽（GSH）来阻止酒精诱导的脂质过氧化。总体，在慢性酒精损害下，富含虫草素的CMα表现出最高的抗氧化剂和高脂血症作用。我们的结果表明CMα可能由于抑制虫草素的抗氧化和降血脂活性，可用于抑制酒精引起的肝病中的氧化和高脂血症。