History of gestational diabetes mellitus (GDM) and serum lipid abnormalities were associated with postpartum impaired glucose tolerance. To investigate the association between concentration of total cholesterol (TC), at the time of GDM diagnosis, and risk of postpartum glucose intolerance. Women who were diagnosed GDM with a live singleton delivery between January 1, 2013 and December 31, 2017 were included. Women were grouped based on the TC quartiles at the time of GDM diagnosis and had an OGTT at 6–12 weeks after delivery. The relationship between TC and the risk of postpartum glucose intolerance was assessed by COX regression. A total of 845 women were in the final analysis. Higher TC quartile at diagnosis of GDM was associated with a decreased risk of postpartum glucose intolerance. Women in the highest TC quartile (>7.0 mmol L− 1) had approximately only half-risk of any postpartum glucose intolerance, compared with women in the lowest TC quartile (<5.5 mmol L− 1). The decreased concentration of TC, at the time of GDM diagnosis, was related to an increased risk of postpartum abnormal glucose regulation in GDM women. Therefore, because both excessively increased and decreased TC were associated with pregnancy and postpartum complications, the optimal concentration of maternal TC throughout pregnancy remained to be further researched.

中文翻译：

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妊娠糖尿病妇女体内总胆固醇与产后糖耐量降低之间的关系。

妊娠糖尿病史（GDM）和血脂异常与产后葡萄糖耐量降低有关。研究GDM诊断时总胆固醇（TC）浓度与产后葡萄糖耐受不良风险之间的关系。纳入了在2013年1月1日至2017年12月31日期间被诊断为GDM并单胎活产的女性。根据GDM诊断时的TC四分位数对妇女进行分组，分娩后6-12周进行OGTT。通过COX回归评估TC与产后葡萄糖耐受不良风险之间的关系。最终分析了845名女性。诊断为GDM时较高的TC四分位数与降低的产后葡萄糖耐受不良风险相关。TC最高四分位数中的女性（> 7。与最低TC四分位数（<5.5 mmol L-1）的女性相比，0 mmol L-1）约有任何产后葡萄糖不耐症的一半风险。GDM诊断时TC浓度降低与GDM妇女产后异常葡萄糖调节风险增加有关。因此，由于TC的过度增加和降低都与妊娠和产后并发症有关，因此整个妊娠期间孕妇TC的最佳浓度仍有待进一步研究。