Vitamin C deficiency may be more common than is generally assumed, and the association between vitamin C deficiency and adverse psychiatric effects has been known for centuries. This paper aims to systematically review the evidence base for the neuropsychiatric effects of vitamin C deficiency. Relevant studies were identified via systematic literature review. Nine studies of vitamin C deficiency, including subjects both with and without the associated physical manifestations of scurvy, were included in this review. Vitamin C deficiency, including scurvy, has been linked to depression and cognitive impairment. No effect on affective or non-affective psychosis was identified. Disparate measurement techniques for vitamin C, and differing definitions of vitamin C deficiency were apparent, complicating comparisons between studies. However, there is evidence suggesting that vitamin C deficiency is related to adverse mood and cognitive effects. The vitamin C blood levels associated with depression and cognitive impairment are higher than those implicated in clinical manifestations of scurvy. While laboratory testing for ascorbic acid can be practically difficult, these findings nonetheless suggest that mental health clinicians should be alerted to the possibility of vitamin C deficiency in patients with depression or cognitive impairment. Vitamin C replacement is inexpensive and easy to deliver, although as of yet there are no outcome studies investigating the neuropsychiatric impact of vitamin C replacement in those who are deficient.

中文翻译：

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维生素C缺乏症对神经精神的影响：系统评价。

维生素C缺乏症可能比通常认为的更为普遍，并且维生素C缺乏症与不良精神病影响之间的关联已有数百年的历史了。本文旨在系统地回顾维生素C缺乏症对神经精神病学影响的证据基础。通过系统的文献综述确定了相关研究。这项综述包括九项维生素C缺乏症的研究，包括患有或未患有坏血病相关身体表现的受试者。维生素C缺乏症（包括坏血病）与抑郁症和认知障碍有关。没有发现对情感或非情感性精神病有影响。维生素C的不同测量技术和维生素C缺乏症的不同定义显而易见，这使研究之间的比较变得复杂。然而，有证据表明维生素C缺乏与不良情绪和认知作用有关。与抑郁症和认知障碍相关的维生素C血药浓度高于坏血病临床表现所含的维生素C血药浓度。尽管抗坏血酸的实验室检测在实践中可能很困难，但这些发现仍建议精神卫生临床医生应警惕抑郁症或认知障碍患者体内维生素C缺乏的可能性。维生素C的替代疗法价格低廉且易于运送，尽管到目前为止，尚无结果研究调查维生素C替代疗法对缺乏者的神经精神影响。与抑郁症和认知障碍相关的维生素C血药浓度高于坏血病临床表现所含的维生素C血药浓度。尽管抗坏血酸的实验室检测在实践中可能很困难，但这些发现仍建议精神卫生临床医生应警惕抑郁症或认知障碍患者体内维生素C缺乏的可能性。维生素C的替代疗法价格低廉且易于运送，尽管到目前为止，尚无结果研究调查维生素C替代疗法对缺乏者的神经精神影响。与抑郁症和认知障碍相关的维生素C血药浓度高于坏血病临床表现所含的维生素C血药浓度。尽管抗坏血酸的实验室检测在实践中可能很困难，但这些发现仍建议精神卫生临床医生应警惕抑郁症或认知障碍患者体内维生素C缺乏的可能性。维生素C的替代疗法价格低廉且易于运送，尽管到目前为止，尚无结果研究调查维生素C替代疗法对缺乏者的神经精神影响。然而，这些发现表明，精神疾病的临床医生应警惕抑郁症或认知障碍患者体内维生素C缺乏的可能性。维生素C的替代疗法价格低廉且易于运送，尽管到目前为止，尚无结果研究调查维生素C替代疗法对缺乏者的神经精神影响。然而，这些发现表明，精神疾病的临床医生应警惕抑郁症或认知障碍患者体内维生素C缺乏的可能性。维生素C的替代疗法价格低廉且易于运送，尽管到目前为止，尚无结果研究调查维生素C替代疗法对缺乏者的神经精神影响。