Magnetic polyelectrolyte microcapsules via water-in-water droplet microfluidics.,Lab on a Chip

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Magnetic polyelectrolyte microcapsules via water-in-water droplet microfluidics.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-06-18 , DOI: 10.1039/d0lc00387e
Maryam Navi ₁ , Jennifer Kieda , Scott S H Tsai

Affiliation

Polyelectrolyte microcapsules (PEMCs) have biocompatible microcompartments. Therefore, PEMCs are useful for applications in cosmetics, food, pharmaceutics, and other industries. The fabrication of PEMCs often involves the use of harsh chemicals or cytotoxic organic phases that make biomedical applications of the microcapsules challenging. In this report, we present an all-aqueous droplet microfluidics platform for the generation of magnetic PEMCs. In the platform, we use an aqueous-two-phase system (ATPS) of polyethylene glycol (PEG) and dextran (Dex), to generate water-in-water droplets, which are magnetically functionalized with ferrofluid. Strong polyelectrolytes (PEs) with opposite charges are used in each ATPS phase. We make emulsion templates of magnetic Dex, containing the polycations, in a continuous phase of PEG. We then apply a magnetic field to move the magnetic droplets to a second PEG phase, which contains the polyanions. By careful tuning of the fluxes of the two PEs in their respective phases, we trigger the formation of a shell at the droplet interface. Owing to the presence of the ferrofluid, the resulting microcapsules are magnetically responsive. We show that the magnetic PEMCs are capable of passive release of large pseudo-drugs as well as triggered release using external stimuli such as osmotic shock and pH change. We expect that magnetic PEMCs from this biocompatible all-aqueous platform will find utility in the fabrication of functionalized drug carriers for targeted drug delivery.

中文翻译：

通过水包水微流控的磁性聚电解质微胶囊。

聚电解质微胶囊（PEMC）具有生物相容性微隔室。因此，PEMC可用于化妆品，食品，制药和其他行业。PEMC的制造通常涉及使用刺激性化学药品或具有细胞毒性的有机相，这使微胶囊的生物医学应用面临挑战。在此报告中，我们介绍了用于产生电磁PEMC的全水液滴微流控平台。在该平台中，我们使用聚乙二醇（PEG）和右旋糖酐（Dex）的水两相系统（ATPS）生成水包水小滴，并用铁磁流体对其进行磁化。在每个ATPS相中都使用带相反电荷的强聚电解质（PE）。我们在PEG的连续相中制备了含有聚阳离子的磁性Dex乳液模板。然后，我们施加磁场以将磁滴移动到包含聚阴离子的第二个PEG相。通过仔细调整两个PE在其各自相中的通量，我们触发了液滴界面处壳的形成。由于铁磁流体的存在，所得的微胶囊具有磁响应性。我们表明，磁性PEMCs能够被动释放大型假药以及使用外部刺激（如渗透压和pH改变）触发释放。我们预计，来自该生物相容性全水平台的磁性PEMC将在用于靶向药物递送的功能化药物载体的制造中找到效用。我们触发液滴界面处壳的形成。由于铁磁流体的存在，所得的微胶囊具有磁响应性。我们表明，磁性PEMCs能够被动释放大型假药以及使用外部刺激（如渗透压和pH改变）触发释放。我们预计，来自该生物相容性全水平台的磁性PEMC将在用于靶向药物递送的功能化药物载体的制造中找到效用。我们触发液滴界面处壳的形成。由于铁磁流体的存在，所得的微胶囊具有磁响应性。我们表明，磁性PEMCs能够被动释放大型假药以及使用外部刺激（如渗透压和pH改变）触发释放。我们预计，来自该生物相容性全水平台的磁性PEMC将在用于靶向药物递送的功能化药物载体的制造中找到效用。

更新日期：2020-08-11

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