Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Skin-interfaced microfluidic devices with one-opening chambers and hydrophobic valves for sweat collection and analysis.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-06-18 , DOI: 10.1039/d0lc00400f Yingxue Zhang 1 , Yao Chen , Jielong Huang , Yangchengyi Liu , Jinfeng Peng , Shangda Chen , Kui Song , Xiaoping Ouyang , Huanyu Cheng , Xiufeng Wang
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-06-18 , DOI: 10.1039/d0lc00400f Yingxue Zhang 1 , Yao Chen , Jielong Huang , Yangchengyi Liu , Jinfeng Peng , Shangda Chen , Kui Song , Xiaoping Ouyang , Huanyu Cheng , Xiufeng Wang
Affiliation
|
Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health. However, sweat loss from the outlet of the microfluidic devices often leads to deviation of the measured concentration of the biomarker or electrolyte from the actual value. Here, we introduce hydrophobic valves at the junction of the chamber and the microfluidic channel as a new chamber design to reduce sweat evaporation. Because the advancing front of the liquid in the hydrophilic microchannel is blocked by the hydrophobic valve, the fluid flows into the chambers, forms the initial meniscus, and completely fills the chambers along the initial meniscus. Fluid dynamic modeling and numerical simulations provide critical insights into the sweat sampling mechanism into the chambers. With significantly reduced evaporation and contamination, the sweat sample can be easily stored for a long time for later analysis when in situ analysis is limited. Additionally, the design with multiple chambers can allow sequential generation of sweat collection at different times for long-term analysis. The in situ real-time measurements of the sweat loss and pH value analysis from the human subject demonstrate the practical utility of the devices in collecting, storing, and analyzing the sweat generated from sweat glands on the skin.
中文翻译：
皮肤接口的微流体装置，带一个开口的腔室和疏水阀，用于汗液收集和分析。
柔软的，与皮肤接触的微流体平台能够捕获，存储和评估汗液化学物质和总的汗水流失，从而为人类生理健康提供了重要的见识。然而，从微流体装置的出口流汗的损失常常导致生物标志物或电解质的测量浓度与实际值的偏离。在这里，我们在腔室和微流体通道的连接处引入疏水阀，作为减少汗液蒸发的新腔室设计。由于亲水性微通道中液体的前进前沿被疏水阀阻塞，因此流体流入腔室，形成初始弯月面，并沿初始弯月面完全充满腔室。流体动力学建模和数值模拟提供了对进入腔室的汗液采样机制的关键见解。汗液样品可大大减少蒸发和污染，可轻松保存很长时间，以备以后分析时使用。原位分析是有限的。此外，具有多个腔室的设计可允许在不同时间连续生成汗液，以进行长期分析。在原位从所述人受试者的汗水损失和pH值分析的实时测量表明在收集，存储和分析从皮肤上的汗腺产生的汗的装置的实用性。
更新日期：2020-07-29
中文翻译：
皮肤接口的微流体装置，带一个开口的腔室和疏水阀，用于汗液收集和分析。
柔软的，与皮肤接触的微流体平台能够捕获，存储和评估汗液化学物质和总的汗水流失，从而为人类生理健康提供了重要的见识。然而，从微流体装置的出口流汗的损失常常导致生物标志物或电解质的测量浓度与实际值的偏离。在这里，我们在腔室和微流体通道的连接处引入疏水阀，作为减少汗液蒸发的新腔室设计。由于亲水性微通道中液体的前进前沿被疏水阀阻塞，因此流体流入腔室，形成初始弯月面，并沿初始弯月面完全充满腔室。流体动力学建模和数值模拟提供了对进入腔室的汗液采样机制的关键见解。汗液样品可大大减少蒸发和污染，可轻松保存很长时间，以备以后分析时使用。原位分析是有限的。此外，具有多个腔室的设计可允许在不同时间连续生成汗液，以进行长期分析。在原位从所述人受试者的汗水损失和pH值分析的实时测量表明在收集，存储和分析从皮肤上的汗腺产生的汗的装置的实用性。
京公网安备 11010802027423号