Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions,Green Chemistry

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Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2020-06-18 , DOI: 10.1039/d0gc00140f
Yi Liu _{1,

2,

3,

4,

5} , Ya-Nan Meng _{1,

2,

3,

4,

5} , Xun-Jie Huang _{1,

2,

3,

4,

5} , Fu-Hua Qin _{1,

2,

3,

4,

5} , Dapeng Wu _{1,

2,

3,

4,

5} , Qianjun Shao _{1,

2,

3,

4,

5} , Zhiyong Guo _{1,

2,

3,

4,

5} , Qiang Li _{6,

7,

8,

9,

10} , Wen-Ting Wei _{1,

2,

3,

4,

5}

Affiliation

Without using any additives, a practical and eco-friendly methodology has been realized for the tandem double cyclization of 1,6-dienes with easily accessible azobis(alkylcarbonitriles) on water. This chemistry has mild reaction conditions, employing water as the sole solvent, with high regioselectivity and ease of scale-up. Moreover, this is the first example of 1,n-diene cyclization using azobis(alkylcarbonitriles) as a two-carbon unit for the construction of polycyclic skeletons.

中文翻译：

在无添加剂条件下用水偶氮双（烷基甲腈）对1,6-二烯进行自由基环化

在不使用任何添加剂的情况下，已经实现了一种实用且环保的方法，用于将1,6-二烯与易于接触的偶氮二（烷基甲腈）在水中串联串联。该化学反应条件温和，以水为唯一溶剂，具有较高的区域选择性和易于放大的特性。此外，这是使用偶氮二（烷基腈）作为二碳单元构建多环骨架的1，n-二烯环化的第一个例子。

更新日期：2020-07-20

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