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Radical cyclization of 1,6-dienes with azobis(alkylcarbonitriles) on water under additive-free conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2020-06-18 , DOI: 10.1039/d0gc00140f
Yi Liu 1, 2, 3, 4, 5 , Ya-Nan Meng 1, 2, 3, 4, 5 , Xun-Jie Huang 1, 2, 3, 4, 5 , Fu-Hua Qin 1, 2, 3, 4, 5 , Dapeng Wu 1, 2, 3, 4, 5 , Qianjun Shao 1, 2, 3, 4, 5 , Zhiyong Guo 1, 2, 3, 4, 5 , Qiang Li 6, 7, 8, 9, 10 , Wen-Ting Wei 1, 2, 3, 4, 5
Affiliation  

Without using any additives, a practical and eco-friendly methodology has been realized for the tandem double cyclization of 1,6-dienes with easily accessible azobis(alkylcarbonitriles) on water. This chemistry has mild reaction conditions, employing water as the sole solvent, with high regioselectivity and ease of scale-up. Moreover, this is the first example of 1,n-diene cyclization using azobis(alkylcarbonitriles) as a two-carbon unit for the construction of polycyclic skeletons.

中文翻译:

在无添加剂条件下用水偶氮双(烷基甲腈)对1,6-二烯进行自由基环化

在不使用任何添加剂的情况下,已经实现了一种实用且环保的方法,用于将1,6-二烯与易于接触的偶氮二(烷基甲腈)在水中串联串联。该化学反应条件温和,以水为唯一溶剂,具有较高的区域选择性和易于放大的特性。此外,这是使用偶氮二(烷基腈)作为二碳单元构建多环骨架的1,n-二烯环化的第一个例子。
更新日期:2020-07-20
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