Engineered scaffolds used to regenerate mammalian tissues should recapitulate the underlying fibrous architecture of native tissue to achieve comparable function. Current fibrous scaffold fabrication processes, such as electrospinning and three-dimensional (3D) printing, possess application-specific advantages, but they are limited either by achievable fiber sizes and pore resolution, processing efficiency, or architectural control in three dimensions. As such, a gap exists in efficiently producing clinically relevant, anatomically sized scaffolds comprising fibers in the 1–100 μm range that are highly organized. This study introduces a new high-throughput, additive fibrous scaffold fabrication process, designated in this study as 3D melt blowing (3DMB). The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries. The fundamental process principles, system design, and key parameters are described, and two examples of the capabilities to create scaffolds for biomedical engineering applications are demonstrated.

中文翻译：

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用于再生医学的 3D 纤维支架的高通量制造。


用于再生哺乳动物组织的工程支架应重现天然组织的底层纤维结构，以实现类似的功能。当前的纤维支架制造工艺，例如静电纺丝和三维（3D）打印，具有特定于应用的优势，但它们受到可实现的纤维尺寸和孔径分辨率、加工效率或三维结构控制的限制。因此，在有效生产临床相关的、符合解剖学尺寸的支架方面存在差距，该支架由高度组织化的 1-100 μm 范围内的纤维组成。本研究介绍了一种新的高通量、添加剂纤维支架制造工艺，在本研究中称为 3D 熔喷 (3DMB)。本研究中描述的 3DMB 系统是由大型非织造布制造机械改造而来，以适应用于组织工程和可植入生物医学设备的体积较小、成本较高的聚合物，并具有纤维收集组件，该组件使用适应性强的机器人技术来创建具有预定几何形状的支架。描述了基本工艺原理、系统设计和关键参数，并演示了为生物医学工程应用创建支架的能力的两个示例。