Extracellular vesicles (EVs) have been known to carry multiple bioactive molecules, including lipids, mRNA/miRNA, and proteins. However, recent studies show that specific DNAs are also packed into EVs secreted by various cells, which are considered as powerful markers for diagnosis and prognosis of disease. DNAs in EVs are derived from parental cells, representing the mutation and even spanning of the whole genomic DNA of parental cells. Interestingly, increasing numbers of studies have found that the genetic materials in different EVs are not only universal but also random and different, which may be related to the size of EVs. In this review, we discuss the different characteristics of DNAs in EVs and the rules of their variation. We hope our review will trigger the continuing exploration of the origins, characteristics, and variations of DNAs in EVs.

中文翻译：

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细胞外囊泡中DNA的特征和变化。

已知细胞外囊泡（EV）携带多种生物活性分子，包括脂质，mRNA / miRNA和蛋白质。但是，最近的研究表明，特定的DNA也被包装到各种细胞分泌的EV中，这被认为是诊断和预后疾病的有力标记。电动汽车中的DNA来源于亲代细胞，代表了亲代细胞整个基因组DNA的突变甚至跨越。有趣的是，越来越多的研究发现，不同电动汽车中的遗传物质不仅通用，而且随机且不同，这可能与电动汽车的大小有关。在这篇综述中，我们讨论了电动汽车中DNA的不同特征及其变化​​规律。我们希望我们的审查能够触发对起源，特征，