During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.

中文翻译：

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五个补骨脂类异戊二烯类黄酮对衰老相关疾病的影响和机制。

在衰老过程中，衰老细胞逐渐积累在器官中。它们分泌促炎细胞因子和其他因子，统称为衰老相关的分泌表型（SASP）。SASP分泌导致“发炎”，这是一种慢性，全身性，不育，低度炎症微环境，是与衰老相关的疾病发展的关键危险因素。补骨脂是延缓衰老和治疗骨质疏松症的传统中草药。补骨脂中的异戊二烯类黄酮是负责其药理学应用的主要生物活性化合物，例如滩涂，巴伐他汀，bavachalcone，isobavachalcone和neobavaisoflavone。在过去的几十年中，关于补骨脂的药理学已经有了一些有希望的研究。这里，