Budding yeast, Saccharomyces cerevisiae, has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanisms and physiological responses of various MAP kinase signaling cascades were studied in detail. Although these MAP kinase pathways are activated by different signals and elicit diverse cellular responses, such as adaptation to stress and mating, they function as an interconnected signaling network, as they influence each other and, in some cases, even share components. Indeed, various stress signaling pathways interfere with pheromone signaling that triggers a distinct cellular differentiation program. However, the molecular mechanisms responsible for this crosstalk are still poorly understood. Here, we review the general topology of the yeast MAP kinase signaling network and highlight recent and new data revealing how conflicting intrinsic and extrinsic signals are interpreted to orchestrate appropriate cellular responses.

芽殖酵母，酿酒酵母，已被广泛用作模型系统来研究响应内部和外部线索的细胞信号传导。酵母是最早详细研究各种 MAP 激酶信号级联反应的结构、反馈机制和生理反应的生物之一。虽然这些 MAP 激酶通路被不同的信号激活并引发不同的细胞反应，例如适应压力和交配，但它们作为一个相互关联的信号网络起作用，因为它们相互影响，在某些情况下甚至共享组件。事实上，各种压力信号通路会干扰触发不同细胞分化程序的信息素信号。然而，导致这种串扰的分子机制仍然知之甚少。这里，