Abstract

Context

Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland.

Objective

To study the role of nesfatin-1 on functions of rat’s thyroid gland exposed to EMRF.

Materials and methods

Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. The experiment extended for 30 days then the plasma nesfatin-1 level, thyroid functions, and thyroid tissue oxidative stress were assessed. Also; histological and immunohistochemical study studies were done to evaluate structural and apoptotic changes of the thyroid gland.

Results

There was a significant decrease in plasma nesfatin-1 level and thyroid functions with an increase in oxidative stress and apoptosis. Interestingly, there was a correlation between nesfatin-1 level and markers of thyroid function, oxidative stress and apoptosis.

Conclusion

Nesfatin-1 plays a role in thyroid dysfunctions of rats exposed to mobile phone radiation.

中文翻译：

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暴露于手机辐射的大鼠血浆 nesfatin-1 水平降低与甲状腺功能障碍、氧化应激和细胞凋亡有关

摘要

语境

暴露于手机的电磁辐射场会导致甲状腺功能障碍，之前的一项研究表明 nesfatin-1 可能会影响甲状腺的功能。

客观的

研究nesfatin-1对暴露于EMRF的大鼠甲状腺功能的影响。

材料和方法

将30只成年雄性大鼠平均分为I组、II组和III组3组。实验延长30天，然后评估血浆nesfatin-1水平、甲状腺功能和甲状腺组织氧化应激。还; 进行了组织学和免疫组织化学研究以评估甲状腺的结构和凋亡变化。

结果

随着氧化应激和细胞凋亡的增加，血浆 nesfatin-1 水平和甲状腺功能显着下降。有趣的是，nesfatin-1 水平与甲状腺功能、氧化应激和细胞凋亡的标志物之间存在相关性。

结论

Nesfatin-1 在暴露于手机辐射的大鼠的甲状腺功能障碍中起作用。