Hyperthermia induced by the alternating magnetic field (AMF) to heat magnetic nanomaterials localized within the tumor has attracted wide attention due to its ability in effective tumor ablation, low side effects, and deep tissue penetration. However, rather strong AMFs are often needed to realize effective magnetic hyperthermia of tumors. Herein, it is discovered that nonmagnetic gallium–indium liquid metal (GaIn LM) above certain sizes prepared by the shearing force could be effectively heated up under AMF with a low field intensity owing to the eddy‐thermal effect, which could be utilized for AMF‐induced hyperthermia treatment of tumors. As demonstrated in experiments using mice bearing subcutaneous 4T1 breast tumors and rats with deeply seated orthotopic liver tumors, local injection of GaIn LM followed by AMF treatment could result in effective ablation of those tumors. With great in vitro biocompatibility, such GaIn LM also shows no appreciable in vivo toxicity to mice within two months. This work thus presents a new type of thermal ablation therapy using nonmagnetic, biocompatible, and injectable LM to ablate tumors under a low‐field‐intensity AMF, with the eddy‐thermal heating mechanism distinctive from that in conventional magnetic hyperthermia therapies using magnetic nanoagents.

中文翻译：

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交变磁场下可注射的非磁性液态金属用于肿瘤的涡流热消融

由于交变磁场（AMF）具有有效消融肿瘤的能力，低副作用和深层组织穿透的能力，因此由交变磁场（AMF）引起的热疗加热了位于肿瘤内的磁性纳米材料引起了广泛的关注。然而，通常需要相当强的AMF来实现肿瘤的有效磁热疗。在此发现，由于涡流热效应，通过剪切力制备的一定尺寸以上的非磁性镓铟液态金属（GaIn LM）可以在低场强的AMF下有效地加热，可用于AMF诱导的肿瘤热疗。如使用带有皮下4T1乳腺肿瘤的小鼠和患有深位原位肝肿瘤的大鼠的实验所证明的，局部注射GaIn LM后再进行AMF治疗可有效消融那些肿瘤。由于GaIn LM具有出色的体外生物相容性，因此在两个月内对小鼠也没有明显的体内毒性。因此，这项工作提出了一种新型的热消融疗法，该疗法采用非磁性，生物相容性和可注射的LM在低场强AMF下消融肿瘤，其涡流-加热加热机制与使用磁性纳米剂的常规磁热疗法不同。