Microbiome Transfer Partly Overrides Lack of IL-1RI Signaling to Alter Hepatic but not Adipose Tissue Phenotype and Lipid Handling following a High-Fat Diet Challenge.,Molecular Nutrition & Food Research

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Microbiome Transfer Partly Overrides Lack of IL-1RI Signaling to Alter Hepatic but not Adipose Tissue Phenotype and Lipid Handling following a High-Fat Diet Challenge.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-18 , DOI: 10.1002/mnfr.202000202
Jessica C Ralston ₁ , Kathleen A J Mitchelson ₁ , Gina M Lynch ₁ , Tam T T Tran _{2,

3} , Hao Wang ₄ , Conall R Strain _{2,

5} , Yvonne M Lenighan ₁ , Elaine B Kennedy ₁ , Catherine Stanton _{2,

5} , Fiona C McGillicuddy _{1,

6} , Qiaozhu Su ₄ , Paul W O'Toole _{2,

3} , Helen M Roche _{1,

4,

6}

Affiliation

IL‐1RI‐mediated inflammatory signaling alters metabolic tissue responses to dietary challenges (e.g., high‐fat diet [HFD]). Recent work suggests that metabolic phenotype is transferrable between mice in a shared living environment (i.e., co‐housing) due to gut microbiome exchange. The authors examine whether the metabolic phenotype of IL‐1RI^−/− mice fed HFD or low‐fat diet (LFD) could be transferred to wild‐type (WT) mice through gut microbiome exchange facilitated by co‐housing.

中文翻译：

微生物组转移在一定程度上克服了 IL-1RI 信号的缺乏，以改变高脂肪饮食挑战后的肝脏而不是脂肪组织表型和脂质处理。

IL-1RI 介导的炎症信号改变了代谢组织对饮食挑战（例如高脂肪饮食 [HFD]）的反应。最近的工作表明，由于肠道微生物组的交换，代谢表型可以在共享生活环境（即合住）的小鼠之间转移。作者研究了喂食 HFD 或低脂饮食 (LFD)的 IL-1RI ^-/-小鼠的代谢表型是否可以通过共同住房促进的肠道微生物组交换转移到野生型 (WT) 小鼠。

更新日期：2020-06-18

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