Chemical Toolbox to Decode the Microbiota Lexicon.,Chemistry - An Asian Journal

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Chemical Toolbox to Decode the Microbiota Lexicon.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-06-18 , DOI: 10.1002/asia.202000541
Yuan Qiao ₁ , Hirohito Hayashi ₁ , Seng Chong Teo ₁

Affiliation

The human microbiota deploys a diverse range of molecules and metabolites to engage in chemical communications with the host, mediating fundamental aspects of host health. Studies of the structures and activities of bioactive molecules produced by the microbiota are imperative to address their implications in microbiota associated diseases in human. By drawing experiences from different research fields, chemists and chemical biologists, who are experts in dealing with chemical molecules, are uniquely positioned to contribute to the emerging knowledge of human microbiota. In this minireview, we discuss the current chemical tools and methods that are pertinent to the discovery of microbiota molecules and metabolites, characterizations of their protein targets, as well as evaluations of their biodistributions in hosts. These are key aspects in understanding the chemical underpinnings of the microbiota‐host interactions that would enable future development of diagnostics and therapeutics targeting the human microbiota.

中文翻译：

化学工具箱，用于解码微生物群词典。

人类微生物群利用多种分子和代谢物与宿主进行化学通讯，从而介导宿主健康的基本方面。必须研究微生物群产生的生物活性分子的结构和活性，以解决它们对人类微生物群相关疾病的影响。通过吸取不同研究领域的经验，化学家和化学生物学家作为处理化学分子的专家，在为人类微生物群新兴知识做出贡献方面具有独特的地位。在这份小型回顾中，我们讨论了与微生物群分子和代谢物的发现，其蛋白质靶标的表征以及它们在宿主中的生物分布评估有关的当前化学工具和方法。

更新日期：2020-07-16

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