Detecting Cysteine in Bioimaging with a Near-Infrared Probe Based on a Novel Fluorescence Quenching Mechanism.,ChemBioChem

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Detecting Cysteine in Bioimaging with a Near-Infrared Probe Based on a Novel Fluorescence Quenching Mechanism.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-18 , DOI: 10.1002/cbic.202000313
Yuanfang Tao ₁ , Xin Ji ₂ , Jian Zhang ₁ , Yue Jin ₁ , Nannan Wang ₁ , Yubing Si ₃ , Weili Zhao _{1,

2}

Affiliation

NIR turn‐on fluorescent probe for detecting Cys: A sensing mechanism based on the different thiol‐induced S_NAr substitution/rearrangement reaction with Cys and Hcy/GSH led to a probe with merits such as large Stokes shift and high linear dynamic range. It has been successfully applied to detect endogenous Cys in living cells and in vivo.