Multiple Chemical Features Impact Biological Performance Diversity of a Highly Active Natural Product-Inspired Library.,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Multiple Chemical Features Impact Biological Performance Diversity of a Highly Active Natural Product-Inspired Library.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-17 , DOI: 10.1002/cbic.202000356
Ryan S Hippman ₁ , Ivan Pavlinov ₁ , Qiwen Gao ₁ , Michelle K Mavlyanova ₁ , Erica M Gerlach ₁ , Leslie N Aldrich ₁

Affiliation

A focused library of natural product‐inspired flavonoids was prepared through diversity‐oriented synthesis with systematic variation of chemical properties, scaffold, stereochemistry, and appendages. The library was evaluated to assess biological performance diversity and to identify chemical diversity elements that predict diverse biological activities.