E‐cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring,Annals of the New York Academy of Sciences

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E‐cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-06-17 , DOI: 10.1111/nyas.14411
Gerard Li ₁ , Yik L Chan _{1,

2} , Baoming Wang _{1,

2} , Sonia Saad _{1,

3} , Jacob George ₄ , Brian G Oliver _{1,

2} , Hui Chen ₁

Affiliation

Approximately 15% of pregnant women vape electronic cigarettes (e‐cigarettes), exposing the fetus to a range of toxic compounds, including nicotine and by‐products of e‐cigarette liquid (e‐liquid) pyrolysis. Owing to the recent emergence of these products, research mainly focuses on immediate users, and not on in utero exposure. Therefore, this study aimed to understand the impact of intrauterine e‐cigarette vapor (e‐vapor) exposure, with and without nicotine, on liver metabolic markers in the male offspring. E‐vapor was generated using an e‐cigarette filled with tobacco‐flavored e‐liquid (18 or 0 mg/mL nicotine). Female Balb/c mice were exposed to e‐vapor for 6 weeks before mating, through gestation and lactation, without direct exposure to the offspring. Livers and plasma from dams and male offspring (13 weeks old) were examined. Exposure to nicotine‐free e‐vapor promoted metabolic changes and liver damage in both the dams and their offspring. Furthermore, exposure to nicotine‐containing e‐vapor did not cause liver damage but induced hepatic steatosis in the adult offspring. Therefore, maternal vaping is detrimental to both the dams and their offspring, with nicotine providing a potential protective effect.

中文翻译：

电子烟损害肝脏并改变怀孕小鼠及其后代的营养代谢

大约 15% 的孕妇吸电子烟（e-香烟），使胎儿暴露在一系列有毒化合物中，包括尼古丁和电子烟液（e-liquid）热解的副产品。由于这些产品最近出现，研究主要集中在直接用户，而不是子宫内暴露。因此，本研究旨在了解宫内电子烟蒸气 (e-vapor) 暴露对雄性后代肝脏代谢标志物的影响，无论是否含有尼古丁。电子蒸汽是使用装有烟草味电子烟液（18 或 0 毫克/毫升尼古丁）的电子烟产生的。雌性 Balb/c 小鼠在交配前、妊娠和哺乳期间暴露于电子蒸汽中 6 周，没有直接暴露于后代。检查了来自水坝和雄性后代（13 周大）的肝脏和血浆。暴露于不含尼古丁的电子蒸汽会促进大坝及其后代的代谢变化和肝损伤。此外，暴露于含尼古丁的电子蒸汽不会导致肝损伤，但会诱发成年后代的肝脂肪变性。因此，母亲吸电子烟对母鼠及其后代都有害，尼古丁可提供潜在的保护作用。

更新日期：2020-06-17

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