Although ultrasound tools for manipulating and permeabilizing suspended cells have been available for nearly a century, accurate prediction of the distribution of acoustic radiation force (ARF) continues to be a challenge. We therefore developed an analytical model of the acoustic radiation force (ARF) generated by a focused Gaussian ultrasound beam incident on a eukaryotic cell immersed in an ideal fluid. The model had three layers corresponding to the nucleus, cytoplasm, and membrane, of a eukaryotic cell. We derived an exact expression for the ARF in relation to the geometrical and acoustic parameters of the model cell components. The mechanics of the cell membrane and nucleus, the relative width of the Gaussian beam, the size, position and aspect ratio of the cell had significant influence on the ARF. The model provides a theoretical basis for improved acoustic control of cell trapping, cell sorting, cell assembly, and drug delivery.

中文翻译：

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聚焦超声波束对悬浮真核细胞的声辐射力

尽管用于操纵和渗透悬浮细胞的超声工具已经问世近一个世纪，但准确预测声辐射力 (ARF) 的分布仍然是一个挑战。因此，我们开发了一种声辐射力 (ARF) 分析模型，该模型由入射在浸入理想流体中的真核细胞上的聚焦高斯超声波束产生。该模型具有三层，分别对应于真核细胞的细胞核、细胞质和细胞膜。我们推导出与模型单元组件的几何和声学参数相关的 ARF 的精确表达式。细胞膜和细胞核的力学、高斯光束的相对宽度、细胞的大小、位置和纵横比对ARF有显着影响。