The ability to study the behavior of cells, proteins, and cell-cell or cell-protein interactions under dynamic forces such as shear stress under fluid flow, provides a more accurate understanding of the physiopathology of hemostasis.

This review touches upon the traditional methods for studying blood coagulation and platelet aggregation and provides an overview on cellular and protein response to shear stress. We also elaborate on the biological aspects of how cells recognize mechanical forces and convert them into biochemical signals that can drive various signaling pathways. We give a detailed description of the various types of microfluidic devices that are employed to study the complex processes of platelet aggregation and blood coagulation under flow conditions as well as to investigate endothelial shear-response. We also highlight works mimicking artificial vessels as platforms to study the mechanisms of coagulation, and finish our review by describing anticipated clinical uses of microfluidics devices and their standardization.

研究细胞、蛋白质和细胞-细胞或细胞-蛋白质相互作用在动态力（例如流体流动下的剪切应力）下的行为的能力，可以更准确地了解止血的生理病理学。

本综述涉及研究血液凝固和血小板聚集的传统方法，并概述了细胞和蛋白质对剪切应力的反应。我们还详细阐述了细胞如何识别机械力并将其转化为可驱动各种信号通路的生化信号的生物学方面。我们详细描述了用于研究流动条件下血小板聚集和血液凝固的复杂过程以及研究内皮剪切反应的各种类型的微流体装置。我们还强调了模仿人造血管作为平台来研究凝血机制的工作，并通过描述微流体设备的预期临床用途及其标准化来完成我们的审查。