Abstract The durability and long-term success of metallic implants are enhanced through the molecular scale design of biocompatible and corrosion resistant surface coatings. To pursue this hypothesis, we have developed a new class of organic-inorganic (O-I) hybrid nanocomposite coatings based on tetramethylorthosilicate (TMOS) and γ-methacryloxypropyltrimethoxysilane (MAPTMS) as organofunctional alkoxysilanes precursors and dimethyltrimethylsilylphosphite (DMTMSP) as a phosphorus precursor. Addition of DMTMSP to TMOS-MAPTMS hybrids increased the extent of intermolecular condensation and cross-linking observed. Both normal human osteoblast in-vitro biocompatibility and corrosion resistance were enhanced in coatings containing DMTMSP. Though increasing phosphorous content correlated with biocompatibility, a compromise in the amount of phosphorus incorporated would be required if corrosion resistance was the most desirable parameter for optimization, at least for single coat systems. Evaluation of the electrochemical behaviour and the in-vitro biocompatibility show that films prepared using these materials by dip coating onto Ti6Al4V alloys offer a promising alternative to simpler coatings and wholly metallic prostheses.

中文翻译：

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溶胶-凝胶法在 Ti6Al4V 合金上制备含磷前驱体的有机-无机杂化涂层：电化学和体外生物相容性评价

摘要 通过生物相容性和耐腐蚀表面涂层的分子尺度设计，提高了金属植入物的耐用性和长期成功率。为了实现这一假设，我们开发了一类新的有机-无机 (OI) 杂化纳米复合涂层，其基于四甲基原硅酸酯 (TMOS) 和 γ-甲基丙烯酰氧基丙基三甲氧基硅烷 (MAPTMS) 作为有机官能烷氧基硅烷前体和二甲基三甲基亚磷酸甲硅烷基 (DMTMSP) 作为磷前体。将 DMTMSP 添加到 TMOS-MAPTMS 杂化物中增加了观察到的分子间缩合和交联的程度。含有 DMTMSP 的涂层增强了正常人成骨细胞的体外生物相容性和耐腐蚀性。虽然增加磷含量与生物相容性有关，如果耐腐蚀性是最理想的优化参数，至少对于单涂层系统而言，则需要在掺入的磷量方面做出妥协。电化学行为和体外生物相容性的评估表明，使用这些材料通过浸涂到 Ti6Al4V 合金上制备的薄膜为更简单的涂层和全金属假体提供了一种有前途的替代方案。