The transient receptor potential (TRP) ion channel family is composed of twenty-seven channel proteins that are ubiquitously expressed in the human body. The TRPV (vanilloid) subfamily has been a recent target of investigation within the cardiovascular field. TRPV1, which is sensitive to heat as well as vanilloids, is the best characterized TRPV channel and is the namesake for the subfamily that includes six members. Research into the function of TRPV2 has suggested that it plays an important role in cardiovascular function.

Over the last twenty years a greater understanding of the differences among the TRPV channels has allowed for more precise experimentation and has opened various translational opportunities. TRPV2 has been found to be a both a mechanosensor and a mediator of calcium handling and has been found to play important roles in healthy and diseased cardiomyocytes. These roles have been translated into clinical studies in patients with muscular dystrophy (both agonism and antagonism) as well as in patients with cardiomyopathy and heart failure with reduced ejection fraction. Its role as a structural protein has also been elucidated, though the clinical significance of this finding has yet to be established.

Despite the clinical progress that has been made there is still a need for large, prospective randomized studies with TRPV2 channel agonists and antagonists in order to bring these basic and translational science findings to the bedside.

瞬时受体电位 (TRP) 离子通道家族由 27 种通道蛋白组成，这些蛋白在人体内普遍存在。TRPV (vanilloid) 亚家族最近成为心血管领域的研究目标。TRPV1 对热和香草素敏感，是特征最好的 TRPV 通道，是包括六个成员的亚科的同名。对 TRPV2 功能的研究表明它在心血管功能中起着重要作用。

在过去的二十年里，对 TRPV 渠道之间差异的更深入了解允许进行更精确的实验，并开辟了各种转化机会。已发现 TRPV2 既是机械传感器又是钙处理的介质，并且已发现在健康和患病心肌细胞中发挥重要作用。这些作用已转化为肌营养不良症（激动和拮抗）患者以及射血分数降低的心肌病和心力衰竭患者的临床研究。它作为结构蛋白的作用也得到了阐明，尽管这一发现的临床意义尚未确定。

尽管已经取得了临床进展，但仍需要对 TRPV2 通道激动剂和拮抗剂进行大型、前瞻性随机研究，以便将这些基础和转化科学发现带到床边。