Three undescribed spirosteroids, asparacemosones A-C, an undescribed spiro-21-norsteroid, asparacemosone D, along with seven known compounds were isolated from Thai herbal plant Asparagus racemosus Willd. roots. Their structures were elucidated by spectroscopic analysis including NMR, UV, IR and mass spectrometry. The absolute configurations of asparacemosones A, B, and D were determined by single crystal X-ray diffraction using CuKα radiation. Among the isolated compounds, the norlignan nyasol and three acetylenic norlignans demonstrated potent α-glucosidase inhibition, with IC50 values ranging from 0.003 to 0.004 μM which is 5 × 104 fold more potent than the standard acarbose.

中文翻译：

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来自总状芦笋 Willd 的螺类固醇和 α-葡萄糖苷酶抑制性降木脂素。根

从泰国草本植物总状芦笋 Willd 中分离出三种未描述的螺类固醇 asparacemosones AC、一种未描述的 spiro-21-norsteroid asparacemosone D 以及七种已知化合物。根。它们的结构通过光谱分析包括核磁共振、紫外、红外和质谱进行了阐明。天冬酰胺酮 A、B 和 D 的绝对构型通过使用 CuKα 辐射的单晶 X 射线衍射确定。在分离的化合物中，降木脂素甲酚和三种炔属降木脂素表现出有效的 α-葡萄糖苷酶抑制作用，IC50 值范围为 0.003 至 0.004 μM，是标准阿卡波糖的 5 × 104 倍。