Oxygen-saturated perfluorohexane-cored, cisplatin (Pt)-decorated hollow gold nanospheres (Pt-HAuNS-PFH@O₂) have been synthesized for ultrasound (US) imaging-guided tumor treatment depending on chemo/photothermal therapy, relief of hypoxia, and photothermal induced US contrast signal. Both NIR laser-induced hyperthermia generation by gold nanospheres and acidity triggered release of Pt resulted in high toxicity after internalization by breast cancer cells. According to ex vivo immunofluorescence investigation and in vivo pharmacodynamic studies on MDA-MB-231 tumor bearing mice, the susceptibility of tumors to Pt-HAuNS-PFH@O₂ was improved by the relief of hypoxia. In addition, US imaging under different conditions verified the amplified US contrast property of Pt-HAuNS-PFH@O₂ by the heat-dependent liquid–gas conversion of PFH. Overall, Pt-HAuNS-PFH@O₂ can be promisingly used as an oxygen self-enriched nanoplatform for US imaging-guided chemo/photothermal therapy.

氧饱和的全氟己烷核修饰的顺铂（Pt）修饰的空心金纳米球（Pt-HAuNS-PFH @ O ₂）已被合成用于超声（US）成像引导的肿瘤治疗，具体取决于化学/光热疗法，缓解缺氧，和光热诱导的US对比信号。金纳米球产生的近红外激光诱导的高温和酸性触发了Pt的释放，乳腺癌细胞内化后均导致了高毒性。根据对MDA-MB-231荷瘤小鼠的离体免疫荧光研究和体内药效学研究，肿瘤对Pt-HAuNS-PFH @ O ₂的敏感性通过缓解缺氧得到改善。此外，在不同条件下的US成像通过热依赖于PFH的液-气转化，验证了Pt-HAuNS-PFH @ O ₂的放大的US对比度特性。总体而言，Pt-HAuNS-PFH @ O ₂有望被用作美国影像引导的化学/光热疗法中的一种自富氧纳米平台。