Abstract Biomimetic functionalization is a pressing need for orthopedic implants to achieve reinforced osseointegration and accelerated osteogenesis, thereby obtaining a successful clinical outcome. To realize bioactivity, Ti Nb alloys with varying Nb contents (0–45 at.%) were additively manufactured using elemental powder blends. The regulation of the Nb contents could balance the surface constituent ratio of Nb2O5 and TiO2, enhancing the formation of the hydroxyl group and surface hydrophilicity. Moreover, the effect mechanism of Nb2O5 on immune modulation and bone regeneration was first put forward. The incorporation of Nb improved the viability of macrophages by inducing a macrophage polarization toward an anti-inflammatory M2-like state. The variation of morphological and up-regulated expression of anti-inflammatory factors led to a more favorable osteoimmune microenvironment for osteogenesis, promoting the osteogenic differentiation of osteoblasts in vitro. Considering the surface constituent and in vitro biological performance, 3D-printed Ti 25Nb scaffolds were placed into the femoral condyle of the rabbit. The Micro-CT and histological analysis indicated that Ti 25Nb scaffolds could accelerate bone regeneration and reinforce bone integration as relative to pure Ti. Overall, the Ti 25Nb scaffold exhibited structural bionic ability, surprising immunomodulatory properties, superior bone regeneration and osseointegration capacity, showing exceptional potential in the treatment of bone defects.

中文翻译：

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含有铌的 3D 打印多孔钛支架具有高骨再生能力

摘要 仿生功能化是骨科植入物的迫切需要，以实现增强的骨整合和加速成骨，从而获得成功的临床结果。为了实现生物活性，使用元素粉末混合物增材制造了具有不同 Nb 含量（0-45 at.%）的 Ti Nb 合金。Nb含量的调节可以平衡Nb2O5和TiO2的表面组成比，增强羟基的形成和表面亲水性。此外，首次提出了Nb2O5对免疫调节和骨再生的作用机制。Nb 的掺入通过诱导巨噬细胞向抗炎 M2 样状态极化，提高了巨噬细胞的活力。形态学的变化和抗炎因子的上调表达导致更有利的骨免疫微环境有利于成骨，促进体外成骨细胞的成骨分化。考虑到表面成分和体外生物学性能，将 3D 打印的 Ti 25Nb 支架放入兔子的股骨髁中。Micro-CT 和组织学分析表明，相对于纯钛，Ti 25Nb 支架可以加速骨再生并增强骨整合。总体而言，Ti 25Nb 支架表现出结构仿生能力、令人惊讶的免疫调节特性、卓越的骨再生和骨整合能力，在治疗骨缺损方面显示出非凡的潜力。在体外促进成骨细胞的成骨分化。考虑到表面成分和体外生物学性能，将 3D 打印的 Ti 25Nb 支架放入兔子的股骨髁中。Micro-CT 和组织学分析表明，相对于纯钛，Ti 25Nb 支架可以加速骨再生并增强骨整合。总体而言，Ti 25Nb 支架表现出结构仿生能力、令人惊讶的免疫调节特性、卓越的骨再生和骨整合能力，在治疗骨缺损方面显示出非凡的潜力。在体外促进成骨细胞的成骨分化。考虑到表面成分和体外生物学性能，将 3D 打印的 Ti 25Nb 支架放入兔子的股骨髁中。Micro-CT 和组织学分析表明，相对于纯钛，Ti 25Nb 支架可以加速骨再生并增强骨整合。总体而言，Ti 25Nb 支架表现出结构仿生能力、令人惊讶的免疫调节特性、卓越的骨再生和骨整合能力，在治疗骨缺损方面显示出非凡的潜力。Micro-CT 和组织学分析表明，相对于纯钛，Ti 25Nb 支架可以加速骨再生并增强骨整合。总体而言，Ti 25Nb 支架表现出结构仿生能力、令人惊讶的免疫调节特性、卓越的骨再生和骨整合能力，在治疗骨缺损方面显示出非凡的潜力。Micro-CT 和组织学分析表明，相对于纯钛，Ti 25Nb 支架可以加速骨再生并增强骨整合。总体而言，Ti 25Nb 支架表现出结构仿生能力、令人惊讶的免疫调节特性、卓越的骨再生和骨整合能力，在治疗骨缺损方面显示出非凡的潜力。