In this case-control study, 68 relapsing-remitting multiple sclerosis (RRMS) patients and 133 control were genotyped for IL1A-889 (rs1800587), IL1B-511 (rs16944), IL1B+3962 (rs1143634), IL1R1pst11970 (rs2234650) and IL1RNmspa1 11,100 (rs315952) variants. Sequence-specific-primer-polymerase-chain-reaction was the genotyping method. Logistic regression analysis demonstrated protective effects of IL1B-511, IL1R1pst11970 and IL1RNmspa1 11,100 against MS incidence, while no association was found with IL1A-889 and IL1B+3962 variants. Allele frequencies showed no significant gender, medication or expanded disability status scale-associated variation. Haplotype analysis suggested 4.31-fold increased odds for MS in subjects with C-T-C-C-T haplotype of the respective loci. In conclusion, IL-1 gene variants influence MS susceptibility in Iraqi population.

中文翻译：

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复发缓解型多发性硬化症：伊拉克患者白细胞介素 1 基因簇多态性的概况

在该病例对照研究中，对 68 名复发缓解型多发性硬化 (RRMS) 患者和 133 名对照患者进行了 IL1A-889 (rs1800587)、IL1B-511 (rs16944)、IL1B+3962 (rs1143634) 和 IL115R115R110ps101111101111111111111111111111112 11,100 (rs315952) 变体。序列特异性引物聚合酶链反应是基因分型方法。Logistic 回归分析表明 IL1B-511、IL1R1pst11970 和 IL1RNmspa1 11,100 对 MS 发病率具有保护作用，而未发现与 IL1A-889 和 IL1B+3962 变体相关。等位基因频率没有显示出与性别、药物或扩大的残疾状态量表相关的变化。单倍型分析表明，在具有相应基因座的 CTCCT 单倍型的受试者中，MS 的几率增加了 4.31 倍。总之，IL-1 基因变异影响伊拉克人群的 MS 易感性。