OBJECTIVES To evaluate alterations of top-down and/or bottom-up attention in migraine and their cortical underpinnings. METHODS 19 migraineurs between attacks and 19 matched control participants performed a task evaluating jointly top-down and bottom-up attention, using visually-cued target sounds and unexpected task-irrelevant distracting sounds. Behavioral responses and magneto- and electro-encephalography signals were recorded. Event-related potentials and fields were processed and source reconstruction was applied to event-related fields. RESULTS At the behavioral level, neither top-down nor bottom-up attentional processes appeared to be altered in migraine. However, migraineurs presented heightened evoked responses following distracting sounds (orienting component of the N1 and Re-Orienting Negativity, RON) and following target sounds (orienting component of the N1), concomitant to an increased recruitment of the right temporo-parietal junction. They also displayed an increased effect of the cue informational value on target processing resulting in the elicitation of a negative difference (Nd). CONCLUSIONS Migraineurs appear to display increased bottom-up orienting response to all incoming sounds, and an enhanced recruitment of top-down attention. SIGNIFICANCE The interictal state in migraine is characterized by an exacerbation of the orienting response to attended and unattended sounds. These attentional alterations might participate to the peculiar vulnerability of the migraine brain to all incoming stimuli.

中文翻译：

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偏头痛的听觉注意力改变：行为和 MEG/EEG 研究

目的 评估偏头痛及其皮质基础中自上而下和/或自下而上注意的变化。方法 19 名偏头痛发作之间的偏头痛患者和 19 名匹配的对照组参与者使用视觉提示的目标声音和意外的与任务无关的分散注意力的声音，共同评估自上而下和自下而上的注意力。记录了行为反应以及脑磁图和脑电图信号。处理事件相关电位和场，并将源重建应用于事件相关场。结果 在行为层面，偏头痛患者的自上而下和自下而上的注意过程似乎都没有改变。然而，偏头痛患者在分散注意力的声音（N1 的定向成分和重新定向负性，RON）和跟随目标声音（N1 的定向成分），伴随着右侧颞顶骨交界处的募集增加。他们还显示提示信息值对目标处理的影响增加，导致负差异 (Nd) 的引出。结论 偏头痛患者似乎对所有传入的声音表现出更多的自下而上的定向反应，以及自上而下的注意力的增强。意义 偏头痛发作间期的特点是对注意和无人注意的声音的定向反应加剧。这些注意力的改变可能与偏头痛大脑对所有传入刺激的特殊脆弱性有关。他们还显示了提示信息值对目标处理的影响增加，从而导致了负差异 (Nd)。结论 偏头痛患者似乎对所有传入的声音表现出更多的自下而上的定向反应，以及自上而下的注意力的增强。意义 偏头痛发作间期的特点是对注意和无人注意的声音的定向反应加剧。这些注意力的改变可能与偏头痛大脑对所有传入刺激的特殊脆弱性有关。他们还显示了提示信息值对目标处理的影响增加，从而导致了负差异 (Nd)。结论 偏头痛患者似乎对所有传入的声音表现出更多的自下而上的定向反应，以及自上而下的注意力的增强。意义 偏头痛发作间期的特点是对注意和无人注意的声音的定向反应加剧。这些注意力的改变可能与偏头痛大脑对所有传入刺激的特殊脆弱性有关。意义 偏头痛发作间期的特点是对注意和无人注意的声音的定向反应加剧。这些注意力的改变可能与偏头痛大脑对所有传入刺激的特殊脆弱性有关。意义 偏头痛发作间期的特点是对注意和无人注意的声音的定向反应加剧。这些注意力的改变可能与偏头痛大脑对所有传入刺激的特殊脆弱性有关。