Qu et al. (2020) demonstrate a peptide-induced targeted degradation of the alpha-synuclein protein, a hallmark of Parkinson’s disease. Using a modular three-component design, the target-protein-specific, cell-permeable peptide disposed of alpha-synuclein via the ubiquitin-proteasome pathway rather than the standard autophagy-lysosome pathway.

中文翻译：

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基于肽的 PROTAC：病理蛋白的捕食者。

曲等。(2020) 展示了肽诱导的α-突触核蛋白的靶向降解，这是帕金森病的标志。使用模块化的三组分设计，目标蛋白特异性、细胞渗透性肽通过泛素-蛋白酶体途径而不是标准的自噬-溶酶体途径处理α-突触核蛋白。