Purpose

Menopause modifies women’s lipid profiles. However, the fact that it is still unclear whether high-density lipoprotein-cholesterol (HDL-C) levels decrease in postmenopausal women necessitated a systematic review and meta-analysis.

Methods

The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched and 498 articles published between 1987 and 2020 were retrieved. Studies reporting HDL-C, low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels in both postmenopausal and premenopausal populations were included. The quality of the included studies was assessed using the Cross-Sectional/Prevalence Study Quality tool. The standard mean difference (SMD) and 95% confidence interval (CI) were estimated using random effects models. A meta-regression analysis and subgroup analysis were performed to identify potential modifiers. Egger’s test and funnel plots were constructed to evaluate publication biases.

Results

Lipid profiles from 18 cross-sectional studies and two cohort studies including 5652 postmenopausal women and 7825 premenopausal women were meta-analyzed. HDL-C levels were not significantly different between the postmenopausal and premenopausal women (SMD = − 0.053, 95% CI − 0.171 to 0.066, p = 0.383) and were not affected by country, publication year, study quality in the meta-regression analysis, or significant publication bias. Higher LDL-C, TC, and TG levels were detected in postmenopausal women than in premenopausal controls.

Conclusion

Unlike increased LDL-C, TC, and TG levels, HDL-C levels in pre- and postmenopausal women were not different in this first meta-analysis of lipid profiles in premenopausal and postmenopausal women. Prospective studies with large populations examining HDL-C levels and functions in women with different menopausal statuses are essential in the future.

Trial registration number

None.

中文翻译：

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HDL-C 水平与更年期之间的关联：荟萃分析。

目的

更年期会改变女性的血脂状况。然而，目前尚不清楚绝经后妇女的高密度脂蛋白胆固醇 (HDL-C) 水平是否降低这一事实需要进行系统评价和荟萃分析。

方法

检索了 PubMed、EMBASE、Cochrane Library 和 Web of Science 数据库，检索了 1987 年至 2020 年间发表的 498 篇文章。研究报告了绝经后和绝经前人群的 HDL-C、低密度脂蛋白胆固醇 (LDL-C)、总胆固醇 (TC) 和甘油三酯 (TG) 水平。使用横断面/患病率研究质量工具评估纳入研究的质量。使用随机效应模型估计标准平均差 (SMD) 和 95% 置信区间 (CI)。进行了元回归分析和亚组分析以确定潜在的修饰符。构建 Egger 检验和漏斗图以评估发表偏倚。

结果

对来自 18 项横断面研究和两项队列研究（包括 5652 名绝经后妇女和 7825 名绝经前妇女）的脂质特征进行了荟萃分析。绝经后和绝经前妇女的 HDL-C 水平没有显着差异（SMD = - 0.053，95% CI - 0.171 至 0.066，p  = 0.383）并且在元回归分析中不受国家、出版年份、研究质量的影响，或显着的发表偏倚。在绝经后女性中检测到的 LDL-C、TC 和 TG 水平高于绝经前对照。

结论

与增加的 LDL-C、TC 和 TG 水平不同，绝经前和绝经后妇女的 HDL-C 水平在对绝经前和绝经后妇女血脂谱的首次荟萃分析中没有差异。未来需要对大量人群进行前瞻性研究，以检查不同更年期女性的 HDL-C 水平和功能。

试用注册号

没有任何。