Retinoic acid-induced protein 2 is a human protein of 530 residues encoded by the RAI2 gene (Q9Y5P3; RAI2_HUMAN). RAI2 is a novel tumor suppressor protein whose depletion in breast cancer cell lines results in the downregulation of several genes associated with differentiation along with increased invasiveness and aggressive tumor phenotype of the cells. The role of the protein is specified to be a transcriptional regulator that promotes chromosomal stability and hence controls the expression of several regulators of cancer and metastasis. Structurally, RAI2 remains an unknown entity and, hence, to obtain a detailed view on the structure function relationship we report the ¹H, ¹³C, and ¹⁵N resonance assignments for the backbone and side chain nuclei of the C-terminal region (a.a. 303–451 of UniProt Q9Y5P3) of RAI2.

中文翻译：

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人视黄酸诱导蛋白 2 的 C 端区域的 1H、13C 和 15N 骨架分配。

视黄酸诱导蛋白 2 是由 RAI2 基因（Q9Y5P3；RAI2_HUMAN）编码的 530 个残基的人类蛋白质。RAI2 是一种新型肿瘤抑制蛋白，其在乳腺癌细胞系中的消耗导致与分化相关的几个基因的下调以及细胞的侵袭性和侵袭性肿瘤表型的增加。该蛋白质的作用被指定为促进染色体稳定性的转录调节因子，从而控制癌症和转移的几种调节因子的表达。在结构上，RAI2 仍然是一个未知实体，因此，为了获得结构函数关系的详细视图，我们报告了¹ H、¹³ C 和¹⁵RAI2 的 C 端区域（UniProt Q9Y5P3 的 aa 303-451）的主链和侧链核的 N 共振分配。