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Copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-06-17 , DOI: 10.1039/d0ob01060j
Xiaomin Wang 1 , Lihong Wang 1 , Shengbiao Yang 1 , Linli Zhang 1 , Yan Li 1 , Qian Zhang 2
Affiliation  

A copper-catalyzed 1,3-aminothiocyanation of arylcyclopropanes with N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl isothiocyanate (TMSNCS) has been developed for the first time, efficiently synthesizing a series of γ-aminothiocyanate derivatives in moderate to excellent yields from readily available substrates under mild conditions. The practicability of the reaction was demonstrated by gram-scale preparation. Furthermore, the easily prepared γ-aminothiocyanate derivatives were verified to be versatile building blocks.

中文翻译:

铜催化的芳基环丙烷的1,3-氨基硫氰化。

首次开发了用N-氟苯磺酰亚胺(NFSI)和三甲基甲硅烷基异硫氰酸酯(TMSNCS)进行的铜催化芳基环丙烷的1,3-氨基硫氰化反应,可有效地从容易获得的底物中高效合成一系列γ-氨基硫氰酸酯衍生物在温和的条件下。通过克规模的制备证明了该反应的实用性。此外,已证实容易制备的γ-氨基硫氰酸酯衍生物是通用的构建基块。
更新日期:2020-07-08
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