Polyelectrolyte stiffness on gold nanorods mediates cell membrane damage.,Nanoscale

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Polyelectrolyte stiffness on gold nanorods mediates cell membrane damage.
Nanoscale ( IF 5.8 ) Pub Date : 2020-06-17 , DOI: 10.1039/d0nr03288c
Nurul 'Ain Azman ₁ , Laurent Bekale , Thanh Xuan Nguyen , James Chen Yong Kah

Affiliation

Charge and surface chemistry of gold nanorods (AuNRs) are often considered the predictive factors for cell membrane damage. Unfortunately, extensive research on AuNR passivated with polyelectrolyte (PE) ligand shell (AuNR-PE) has hitherto left a vital knowledge gap between the mechanical stability of the ligand shell and the cytotoxicity of AuNR-PEs. Here, the agreement between unbiased coarse-grained molecular dynamics (CGMD) simulation and empirical outcomes on hemolysis of red blood cells by AuNR-PEs demonstrates for the first time, a direct impact of the mechanical stability of the PE shell passivating the AuNRs on the lipid membrane rupture. Such mechanical stability is ultimately modulated by the rigidity of the PE components. The CGMD simulation results also reveal the mechanism where the PE chain adsorbs near the surface of the lipid bilayer without penetrating the hydrophobic core of the bilayer, which allows the hydrophobic AuNR core to be in direct contact with the hydrophobic interior of the lipid bilayer, thereby perforating the lipid membrane to induce membrane damage.

中文翻译：

金纳米棒上的聚电解质刚度介导细胞膜损伤。

金纳米棒（AuNRs）的电荷和表面化学通常被认为是细胞膜损伤的预测因素。不幸的是，迄今为止，对用聚电解质（PE）配体壳（AuNR-PE）钝化的AuNR的广泛研究在配体壳的机械稳定性和AuNR-PE的细胞毒性之间留下了重要的知识空白。在此，无偏粗粒分子动力学（CGMD）模拟与AuNR-PEs对红细胞溶血的经验结果之间的一致性首次证明，PE壳钝化AuNRs对PE壳的机械稳定性的直接影响是钝化的。脂质膜破裂。这种机械稳定性最终由PE组件的刚性来调节。

更新日期：2020-07-09

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