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Stem Cells: A Review Encompassing the Literature with a Special Focus on the Side-Lined Miraculous Panacea; Pre-Morula Stem Cells.
Current Stem Cell Research & Therapy ( IF 2.1 ) Pub Date : 2020-05-01 , DOI: 10.2174/1574888x15666200311141731
Aryendu K Saini 1 , Rakesh Saini 2 , Himanshu Bansode 1 , Anurag Singh 1 , Lalita Singh 1
Affiliation  

Stem cells are the undifferentiated cells in the body that possess the ability to differentiate and give rise to any type of cells in the body. In recent years, there has been a growing interest in therapies involving stem cells as different treatment methods got developed. Depending on the source, there are two major kinds of stem cells, embryonic and adult stem cells. The former type is found in the embryo at the different developmental stages before the implantation and excels the latter owing to pluripotency. On the premise of the attributes of stem cells, they are touted as the "panacea for all ills" and are extensively sought for their potential therapeutic roles. There are a lot of robust pieces of evidence that have proved to cure the different ailments in the body like Huntington disease, Parkinson's disease, and Spinal cord injury with stem cell therapy but associated with adverse effects like immune rejection and teratoma formation. In this regard, the pre-morula (isolated at an early pre-morula stage) stem cells (PMSCs) are one of its kind of embryonic stem cells that are devoid of the aforementioned adverse effects. Taking the beneficial factor into account, they are being used for the treatment of disorders like Cerebral palsy, Parkinson's disorder, Aplastic anemia, Multiple sclerosis and many more. However, it is still illegal to use stem cells in the abovementioned disorders. This review encompasses different stem cells and emphasizes on PMSCs for their uniqueness in therapy as no other previously published literature reviews have taken these into consideration. Later in the review, current regulatory aspects related to stem cells are also considered.



中文翻译:

干细胞:综述涵盖文学,侧重于神奇的灵丹妙药;桑蚕前干细胞。

干细胞是人体内未分化的细胞,具有分化能力并在体内产生任何类型的细胞。近年来,随着干细胞疗法的发展,人们对干细胞疗法的兴趣日益浓厚。根据来源,干细胞有两种主要类型,胚胎干细胞和成体干细胞。前者在植入前的不同发育阶段见于胚胎中,由于多能性而优于后者。在干细胞特性的前提下,它们被誉为“所有疾病的灵丹妙药”,并因其潜在的治疗作用而广受追捧。有大量可靠的证据可以治愈人体的各种疾病,例如亨廷顿病,帕金森氏病,干细胞疗法治疗脊髓损伤,但会产生不良反应,例如免疫排斥和畸胎瘤形成。在这方面,桑mor前(在桑pre前早期分离)干细胞(PMSC)是其胚胎干细胞中的一种,其没有上述不利影响。考虑到有益因素,它们被用于治疗诸如脑瘫,帕金森氏病,再生障碍性贫血,多发性硬化症等疾病。然而,在上述疾病中使用干细胞仍然是非法的。这篇综述涵盖了不同的干细胞,并强调了PMSCs在治疗中的独特性,因为以前没有其他文献发表将这些考虑在内。在稍后的评论中,

更新日期:2020-05-01
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