The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A ≥ 8 or/and HADS-D ≥ 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Anchor- and distribution-based methods were used to estimate the MCID. HADS-A and HADS-D improved in response to PR in both patients with bronchiectasis and those with COPD (median (25th, 75th centile)/mean (95% confidence interval) change: HADS-A change: bronchiectasis −2 (−5, 0), COPD −2 (−4, 0); p = 0.43 and HADS-D change: bronchiectasis −2 (−2 to −1), COPD −2 (−3 to −2); p = 0.16). Using 26 estimates, the MCID for HADS-A and HADS-D was −2 points. HADS-A and HADS-D are responsive to PR in patients with bronchiectasis and symptoms of mood disorder, with an MCID estimate of −2 points.

这项研究的目的是评估与支气管扩张症患者的匹配组相比，医院焦虑和抑郁量表-焦虑量表（HADS-A）和焦虑-抑郁量表（HADS-D）量表对支气管扩张患者的肺康复（PR）的反应性。慢性阻塞性肺疾病（COPD）的患者，并提供支气管扩张患者HADS-A和HADS-D的最小临床重要差异（MCID）的估算值。患有支气管扩张且至少轻度焦虑或抑郁（HADS-A≥8或/和HADS-D≥8）的患者以及倾向评分匹配的COPD患者对照组接受了为期8周的门诊PR程序（每周两次监督课程）。计算组内和组间变化以响应PR。使用基于锚和分布的方法来估计MCID。p＝ 0.43且HADS-D改变：支气管扩张-2（-2至-1），COPD-2（-3至-2）；p = 0.16）。使用26个估算值，HADS-A和HADS-D的MCID为-2点。HADS-A和HADS-D对支气管扩张和情绪障碍症状的患者的PR敏感，MCID估计为-2分。