As research on human applications of CRISPR advances, researchers, advisory bodies, and other stakeholder organizations continue calling for global public discourses and engagement to shape the development of human gene editing (HGE). Research that captures public views and tests ways for engaging across viewpoints is vital for facilitating these discourses. Unfortunately, such research lags behind advances in HGE research and applications. Here, we provide the first review of nationally representative public-opinion surveys focused on HGE to discuss limitations and remaining gaps, illustrating how these gaps hinder interpretation of existing studies. Rigorous research with proper methods for capturing representative public opinion of HGE is limited, especially in countries outside of the United States and on a global scale. The result is severely restricted understanding of even the surface level of public views concerning HGE. We identify broad areas where we need more and better research capturing public views, and describe how future surveys can help collect insights necessary for discourse and decision making on HGE.

中文翻译：

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我们（不）对人类基因编辑的全球观点了解多少？CRISPR时代的洞察与盲点

随着 CRISPR 人类应用研究的进展，研究人员、咨询机构和其他利益相关者组织继续呼吁全球公共讨论和参与，以塑造人类基因编辑 (HGE) 的发展。捕捉公众观点并测试跨观点参与方式的研究对于促进这些话语至关重要。不幸的是，此类研究落后于 HGE 研究和应用的进展。在这里，我们首次审查了针对 HGE 的具有全国代表性的民意调查，以讨论局限性和仍然存在的差距，说明这些差距如何阻碍对现有研究的解释。用适当的方法来捕捉 HGE 的代表性公众意见的严格研究是有限的，尤其是在美国以外的国家和全球范围内。结果是严重限制了对公众对 HGE 观点甚至表面水平的理解。我们确定了需要更多更好的研究来捕捉公众观点的广泛领域，并描述了未来的调查如何帮助收集对 HGE 的讨论和决策制定所需的见解。