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Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis.
Organic Letters ( IF 4.9 ) Pub Date : 2020-06-17 , DOI: 10.1021/acs.orglett.0c01471 Łukasz Woźniak 1 , Adam A Rajkiewicz 2 , Louis Monsigny 2 , Anna Kajetanowicz 1, 2 , Karol Grela 2
Organic Letters ( IF 4.9 ) Pub Date : 2020-06-17 , DOI: 10.1021/acs.orglett.0c01471 Łukasz Woźniak 1 , Adam A Rajkiewicz 2 , Louis Monsigny 2 , Anna Kajetanowicz 1, 2 , Karol Grela 2
Affiliation
The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda–Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan.
中文翻译:
烯烃交叉复分解法制备功能化的α,β-不饱和磺酰胺。
已经开发了通过乙烯基磺酰胺和烯烃的交叉复分解合成官能化的α,β-不饱和磺酰胺。在Hoveyda-Grubbs催化剂及其硝基类似物的存在下,反应可顺利进行,提供了广泛的取代产物。在制备生物活性成分的新衍生物莫西沙星和那拉曲普坦中已证明了该方法的有效性。
更新日期:2020-07-02
中文翻译:
烯烃交叉复分解法制备功能化的α,β-不饱和磺酰胺。
已经开发了通过乙烯基磺酰胺和烯烃的交叉复分解合成官能化的α,β-不饱和磺酰胺。在Hoveyda-Grubbs催化剂及其硝基类似物的存在下,反应可顺利进行,提供了广泛的取代产物。在制备生物活性成分的新衍生物莫西沙星和那拉曲普坦中已证明了该方法的有效性。