Rhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams.,Organic Letters

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Rhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams.
Organic Letters ( IF 4.9 ) Pub Date : 2020-06-17 , DOI: 10.1021/acs.orglett.0c01606
Benoit Audic ₁ , Nicolai Cramer ₁

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A Cp*Rh(III)-catalyzed C–H/C–C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping of the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access to synthetically valuable α-alkoxylated γ-lactams with trans diastereoselectivity.

中文翻译：

铑（III）催化的环丙烷CH / CC活化序列可提供非对映选择性地进入α-烷氧基化的γ-内酰胺。

已经开发出了Cp * Rh（III）催化的环丙基异羟肟酸酯的C–H / C–C键激活序列。三组分过程允许用重氮丙二酸酯和醇亲核试剂捕获中间的铑环，从而提供具有反式非对映选择性的合成有价值的α-烷氧基化γ-内酰胺。

更新日期：2020-07-02

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