Synthetic chloride transporters are potential therapeutic agents for cystic fibrosis and cancer. Reported herein are macrocyclic transmembrane chloride transporters prepared by a one-pot condensation reaction. The most efficient macrocycle possesses a fine balance of hydrophobicity for membrane permeation and hydrophilicity for ion recognition. The macrocycle transports chloride ions by forming channels in the membrane. Hydrogen bonds and anion−π interactions assist chloride transport.

中文翻译：

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通过一锅缩合反应的大环跨膜阴离子转运蛋白。

合成氯化物转运蛋白是用于囊性纤维化和癌症的潜在治疗剂。本文报道的是通过一锅缩合反应制备的大环跨膜氯化物转运蛋白。最有效的大环化合物具有疏水性（用于膜渗透）和亲水性（用于离子识别）之间的良好平衡。大环通过在膜上形成通道来传输氯离子。氢键和阴离子-π相互作用有助于氯化物的运输。