Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns. The AgNP λ-max peak was at approximately 405 nm. In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm. ZDV was determined in the range of 50–500 μM, and the detection limit value was obtained as 42 μM. The sensor was used to determine ZDV in tablets with good recovery.

中文翻译：

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基于 β-环糊精功能化银纳米颗粒的比色传感器，用于齐多夫定灵敏测定。


齐多夫定 (ZDV) 是一种抗 HIV 病毒药物，于 1987 年 3 月获得 FDA 批准。它是一种逆转录酶抑制剂。这种药物可以阻止 DNA 的复制并减少患者血液中的病毒数量。由于能够形成各种分子键，银纳米颗粒 (AgNP) 被广泛用于检测包括药物在内的多种试剂。在本研究中，我们采用绿色合成法合成了AgNP修饰的β-环糊精（ β -CD），用于灵敏、选择性齐多夫定（ZDV）测定。使用不同的方法对纳米颗粒进行表征，包括红外 (IR) 光谱、紫外-可见 (UV-Vis) 光谱、透射电子显微镜 (TEM) 以及 X 射线衍射 (XRD) 图案。 AgNP λ最大峰位于约 405 nm 处。在 ZDV 存在下，黄色溶液变成红色，表面等离子体吸收带明显集中在 560 nm 处。 ZDV 测定范围为 50~500 μM ，检测限值为 42 μM 。该传感器用于测定片剂中的 ZDV，回收率良好。