Neuronal hyperexcitability has emerged as a potential biomarker of late-onset early-stage Alzheimer’s disease (LEAD). We hypothesize that the aging-related posterior cortical hyperexcitability anticipates the loss of excitability with the emergence of impairment in LEAD. To test this hypothesis, we compared the behavioral and neurophysiological responses of young and older (ON) normal adults, and LEAD patients during a visuospatial attentional control task. ONs show frontal cortical signal incoherence and posterior cortical hyper-responsiveness with preserved attentional control. LEADs lose the posterior hyper-responsiveness and fail in the attentional task. Our findings suggest that signal incoherence and cortical hyper-responsiveness in aging may contribute to the development of functional impairment in LEAD.

中文翻译：

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老年期的过度兴奋在阿尔茨海默氏症中消失了：所有的兴奋是什么？

神经元过度兴奋已成为晚发性早期阿尔茨海默病 (LEAD) 的潜在生物标志物。我们假设与衰老相关的后皮质过度兴奋性预期随着 LEAD 损伤的出现而失去兴奋性。为了验证这一假设，我们在视觉空间注意力控制任务中比较了年轻和年长 (ON) 正常成年人和 LEAD 患者的行为和神经生理反应。ONs 显示额叶皮层信号不连贯和后皮层高反应性，同时保留注意力控制。LEAD 失去后部高反应性并在注意力任务中失败。我们的研究结果表明，衰老过程中的信号不连贯和皮质高反应性可能导致 LEAD 功能障碍的发展。