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Silk Fibroin: An Emerging Biocompatible Material for Application of Enzymes and Whole Cells in Bioelectronics and Bioanalytical Sciences
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-16 , DOI: 10.1021/acsbiomaterials.9b01971 Sharbani Kaushik 1 , Phurpa Dema Thungon 2 , Pranab Goswami 2
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-06-16 , DOI: 10.1021/acsbiomaterials.9b01971 Sharbani Kaushik 1 , Phurpa Dema Thungon 2 , Pranab Goswami 2
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Enzymes and whole cells serve as the active biological entities in a myriad of applications including bioprocesses, bioanalytics, and bioelectronics. Conserving the natural activity of these functional biological entities during their prolonged use is one of the major goals for validating their practical applications. Silk fibroin (SF) has emerged as a biocompatible material to interface with enzymes as well as whole cells. These biomaterials can be tailored both physically and chemically to create excellent scaffolds of different forms such as fibers, films, and powder for immobilization and stabilization of enzymes. The secondary structures of the SF-protein can be attuned to generate hydrophobic/hydrophilic pockets suitable to create the biocompatible microenvironments. The fibrous nature of the SF protein with a dominant hydrophobic property may also serve as an excellent support for promoting cellular adhesion and growth. This review compiles and discusses the recent literature on the application of SF as a biocompatible material at the interface of enzymes and cells in various fields, including the emerging area of bioelectronics and bioanalytical sciences.
中文翻译：
丝素蛋白：一种新兴的生物相容性材料，用于在生物电子学和生物分析科学中应用酶和全细胞
酶和全细胞在包括生物过程，生物分析和生物电子学在内的许多应用中都充当了活跃的生物实体。这些功能生物实体在长期使用期间保持自然活性是验证其实际应用的主要目标之一。丝素蛋白（SF）已作为一种生物相容性材料出现，可与酶以及整个细胞相互作用。可以对这些生物材料进行物理和化学定制，以创建不同形式的出色支架，例如纤维，薄膜和粉末，以固定和稳定酶。SF蛋白的二级结构可被调节以产生适于产生生物相容性微环境的疏水/亲水口袋。SF蛋白具有显着的疏水特性的纤维性质也可以用作促进细胞粘附和生长的极佳支持。这篇综述汇编和讨论了有关SF在各种领域（包括新兴的电子学和生物分析科学领域）作为酶和细胞界面的生物相容性材料的应用的最新文献。
更新日期：2020-08-10
中文翻译：
丝素蛋白：一种新兴的生物相容性材料，用于在生物电子学和生物分析科学中应用酶和全细胞
酶和全细胞在包括生物过程，生物分析和生物电子学在内的许多应用中都充当了活跃的生物实体。这些功能生物实体在长期使用期间保持自然活性是验证其实际应用的主要目标之一。丝素蛋白（SF）已作为一种生物相容性材料出现，可与酶以及整个细胞相互作用。可以对这些生物材料进行物理和化学定制，以创建不同形式的出色支架，例如纤维，薄膜和粉末，以固定和稳定酶。SF蛋白的二级结构可被调节以产生适于产生生物相容性微环境的疏水/亲水口袋。SF蛋白具有显着的疏水特性的纤维性质也可以用作促进细胞粘附和生长的极佳支持。这篇综述汇编和讨论了有关SF在各种领域（包括新兴的电子学和生物分析科学领域）作为酶和细胞界面的生物相容性材料的应用的最新文献。
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