The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow.,Accounts of Chemical Research

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The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow.
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-06-16 , DOI: 10.1021/acs.accounts.0c00199
Doris Dallinger _{1,

2} , Bernhard Gutmann _{1,

2} , C Oliver Kappe _{1,

2}

Affiliation

In recent years, a steadily growing number of chemists, from both academia and industry, have dedicated their research to the development of continuous flow processes performed in milli- or microreactors. The common availability of continuous flow equipment at virtually all scales and affordable cost has additionally impacted this trend. Furthermore, regulatory agencies such as the United States Food and Drug Administration actively encourage continuous manufacturing of active pharmaceutical ingredients (APIs) with the vision of quality and productivity improvements. That is why the pharmaceutical industry is progressively implementing continuous flow technologies. As a result of the exceptional characteristics of continuous flow reactors such as small reactor volumes and remarkably fast heat and mass transfer, process conditions which need to be avoided in conventional batch syntheses can be safely employed. Thus, continuous operation is particularly advantageous for reactions at high temperatures/pressures (novel process windows) and for ultrafast, exothermic reactions (flash chemistry).

中文翻译：

化学生成器的概念：现场按需连续生产危险试剂。

近年来，来自学术界和工业界的化学家人数不断增加，他们的研究致力于开发在微反应器或微反应器中进行的连续流动过程。几乎所有规模的连续流设备的普遍可用性和可承受的成本也进一步影响了这一趋势。此外，诸如美国食品和药物管理局之类的监管机构也积极鼓励不断改进活性药物成分（API）的生产，以期提高质量和生产率。因此，制药行业正在逐步实施连续流技术。由于连续流反应器的卓越特性，例如反应器体积小以及传热和传质非常快，可以安全地采用常规批生产中需要避免的工艺条件。因此，连续操作对于高温/高压下的反应（新颖的工艺窗口）和超快的放热反应（快速化学反应）特别有利。

更新日期：2020-07-21

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