Previously, sex-dependent alterations in energy homeostasis were reported in adult mice fed a standard chow attributed to exposure to a mixture of organophosphate flame retardants (OPFRs) via estrogen receptors (ERα). In this study, adult male and female mice (C57BL/6J; Taconic) were treated with the same mixture of OPFRs (1 mg/kg each of tricresyl phosphate (TCP), triphenyl phosphate (TPP), and tris(1-3-dichloro-2propyl)phosphate (TDCPP)) for 7 weeks on a low-fat diet (LFD, 10% kcal fat) or a high fat (HFD, 45% kcal fat) in a diet-induced obesity model. Consistent with our previous observations, OPFRs altered weight gain in males, differentially with diet, while females remained unaffected. OPFR treatment also revealed sex-dependent perturbations in metabolic activity. During the night (approximately 0100–0400 hr), males exhibited elevated activity and oxygen consumption, while in females these parameters were decreased, irrespective of diet. OPFR disrupted feeding behavior and abolished diurnal water intake patterns in females while increasing nighttime fluid consumption in males. Despite no marked effect of OPFRs on glucose or insulin tolerance, OPFR treatment altered circulating insulin and leptin in females and ghrelin in males. Data indicate that adult OPFR exposure might influence, and perhaps exacerbate, the effects of diet-induced obesity in adult mice by altering activity, ingestive behavior, and metabolism.

以前，据报道，喂食标准饲料的成年小鼠的性别动态平衡与性别有关，这归因于通过雌激素受体（ERα）暴露于有机磷酸酯阻燃剂（OPFRs）的混合物。在这项研究中，成年雄性和雌性小鼠（C57BL / 6J; Taconic）用相同的OPFRs混合物（磷酸三甲苯酯（TCP），磷酸三苯酯（TPP）和tris（1-3-在饮食诱发的肥胖模型中，低脂饮食（LFD，10％大卡脂肪）或高脂肪食物（HFD，45％大卡脂肪）中使用二氯-2-丙基）磷酸酯（TDCPP）治疗7周。与我们之前的观察结果一致，OPFRs改变了男性的体重增加，与饮食不同，而女性则不受影响。OPFR治疗还显示出代谢活动中的性别依赖性扰动。在夜间（大约0100–0400小时），男性表现出较高的活动性和耗氧量，而女性则不考虑饮食而降低了这些参数。OPFR破坏了雌性的进食行为并废除了昼夜取水方式，同时增加了雄性的夜间饮水量。尽管OPFR对葡萄糖或胰岛素耐受性无显着影响，但OPFR治疗改变了女性的循环胰岛素和瘦素，男性的ghrelin。数据表明，成年OPFR暴露可能通过改变活性，摄食行为和新陈代谢而影响成年小鼠饮食诱发的肥胖症的影响，甚至可能加剧。尽管OPFR对葡萄糖或胰岛素耐受性无显着影响，但OPFR治疗改变了女性的循环胰岛素和瘦素，男性的ghrelin。数据表明，成年OPFR暴露可能通过改变活性，摄食行为和新陈代谢而影响成年小鼠饮食诱发的肥胖症的影响，甚至可能加剧。尽管OPFR对葡萄糖或胰岛素耐受性无显着影响，但OPFR治疗改变了女性的循环胰岛素和瘦素，男性的ghrelin。数据表明，成年OPFR暴露可能通过改变活性，摄食行为和新陈代谢而影响成年小鼠饮食诱发的肥胖症的影响，甚至可能加剧。