Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (¹⁶O) and protons (¹H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.

中文翻译：

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在小鼠模型中与低剂量空间型辐射暴露相关的血浆脂质组变化的鉴定。

在深空执行任务期间，长期暴露于低剂量空间辐射可能会对人体健康产生不利影响。常规剂量测定，前驱症状监测和外周淋巴细胞计数作为器官和组织特异性放射损伤（尤其是在放射暴露后数周或数月出现的损伤）的生物标志物，具有有限的价值。为了评估使用血浆代谢和脂质组学谱作为空间辐射损伤的生物标志物的可行性，我们使用了暴露于低剂量氧离子（¹⁶ O）和质子（¹H）。将血浆概况与暴露于γ射线的小鼠的血浆概况进行比较。我们的结果证明了甘油磷脂代谢，氨基酸代谢以及脂肪酸代谢的重大变化。我们还观察到血脂异常和脂质过氧化，提示在暴露于低剂量的高剂量线性能量传递（LET）辐射后，炎症表型可能对整体健康产生长期影响。