Cardiovascular disease (CVD) is the leading cause of death worldwide. There are numerous factors involved in the development of CVD. Among these, lipids have an important role in maintaining the myocardial cell structure as well as cardiac function. Fatty acids (FA) are utilized for energy, but also contribute to the pathogenesis of CVD and heart failure. Advances in mass spectrometry methods have enabled the comprehensive analysis of a plethora of lipid species from a single sample comprised of a heterogeneous population of lipid molecules. Determining cardiac lipid alterations in different models of CVD identifies novel biomarkers as well as reveals molecular mechanisms that underlie disease development and progression. This information could inform the development of novel therapeutics in the treatment of CVD. Herein, we provide a review of recent studies of cardiac lipid profiles in myocardial infarction, obesity, and diabetic and dilated cardiomyopathy models of CVD by methods of mass spectrometry analysis.

中文翻译：

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心血管疾病模型中的心脏脂质组。


心血管疾病（CVD）是全世界死亡的主要原因。 CVD 的发生涉及多种因素。其中，脂质对于维持心肌细胞结构以及心脏功能具有重要作用。脂肪酸 (FA) 用于提供能量，但也会导致 CVD 和心力衰竭的发病机制。质谱方法的进步使得能够对由异质脂质分子群组成的单个样品中的多种脂质种类进行全面分析。确定不同 CVD 模型中心脏脂质的变化可以识别新的生物标志物，并揭示疾病发生和进展的分子机制。这些信息可以为治疗 CVD 的新疗法的开发提供信息。在此，我们通过质谱分析方法对心肌梗死、肥胖、糖尿病和扩张型心肌病模型的心血管疾病模型的心脏脂质谱的最新研究进行了综述。