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Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome.
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-06-17 , DOI: 10.1111/febs.15430
David A Dougan 1 , Regina Alver 2, 3 , Kürşad Turgay 2, 3
Affiliation  

Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two‐hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1‐interacting proteins. Comment on: https://doi.org/10.1111/febs.15335
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中文翻译:

探索结核分枝杆菌的潜在致命弱点:定义ClpC1相互作用基因组。

蛋白质降解不仅在正常的生理条件下而且在对压力的响应中,在细胞的正确维护中都起着至关重要的作用。在人类病原体Mtb中,这项至关重要的细胞任务是由与多种细胞活性蛋白酶(包括ClpC1P)相关的几种ATPase来完成的。Ziemski。进行了细菌腺苷酸环化酶双杂交筛选以鉴定ClpC1底物,并显示II型TA系统代表了ClpC1相互作用蛋白的主要组成部分。评论:https://doi.org/10.1111/febs.15335
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更新日期:2020-06-17
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