Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.,Glia

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Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.
Glia ( IF 5.4 ) Pub Date : 2020-06-17 , DOI: 10.1002/glia.23877
Benjamin E Clarke _{1,

2} , Doaa M Taha _{1,

2} , Giulia E Tyzack _{1,

2} , Rickie Patani _{1,

2}

Affiliation

Increasing evidence has suggested that astrocytes demonstrate striking regionally allocated functional heterogeneity. Here, we discuss how this spatiotemporally encoded diversity determines the astrocytic phenotype along a finely grained spectrum from neuroprotective to deleterious states. With increasing recognition of their diverse and evolving roles in the central neuraxis, astrocytes now represent a tractable cellular target for therapies aiming to restore neural circuit integrity in a broad range of neurodegenerative disorders. Understanding the determinants of astrocyte physiology along with the true extent of heterogeneity in their regional and subregional functions will ultimately inform therapeutic strategy in neurodegenerative diseases.

中文翻译：

星形胶质细胞在健康和疾病中的区域编码功能异质性：一个观点。

越来越多的证据表明，星形胶质细胞表现出惊人的区域分配功能异质性。在这里，我们讨论了这种时空编码的多样性如何沿着从神经保护状态到有害状态的细粒度谱确定星形细胞表型。随着人们越来越认识到它们在中枢神经轴中的多样化和不断发展的作用，星形胶质细胞现在代表了一种易于处理的细胞靶点，用于在广泛的神经退行性疾病中恢复神经回路的完整性。了解星形胶质细胞生理学的决定因素以及其区域和次区域功能异质性的真实程度将最终为神经退行性疾病的治疗策略提供信息。

更新日期：2020-06-17

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