The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis.,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-17 , DOI: 10.1002/cbic.202000229
Benjamin Nji Wandi ₁ , Vilja Siitonen ₁ , Kaisa Palmu ₁ , Mikko Metsä-Ketelä ₁

Affiliation

Order! The binding of nogalamycin to DNA is facilitated by its carbohydrate units. The 2“‐ and 4”‐hydroxy groups of l‐nogalamine are particularly important for the bioactivity due to hydrogen bonding interactions. We have elucidated the biosynthetic steps for l‐nogalamine formation and show that SnoT installs the 2“‐hydroxy group, followed by 2–5”‐carbocyclization and 4“‐epimerization by SnoK and SnoN, respectively.

中文翻译：

Rieske加氧酶SnoT催化Nogalamycin生物合成过程中l-Rhodosamine的2''-羟基化反应。

订购！Nogalamycin与DNA的结合是通过其碳水化合物单元促进的。的2“ -和4”的基团羟基升-nogalamine是用于生物活性特别重要的是由于氢键相互作用。我们阐明了l-诺加拉敏形成的生物合成步骤，并表明SnoT安装了2”-羟基，然后分别通过SnoK和SnoN进行了2–5”-碳环化和4”-表麻化。

更新日期：2020-06-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11