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Malaria According to GARP: A New Trail towards Anti-disease Vaccination.
Trends in Parasitology ( IF 7.0 ) Pub Date : 2020-06-17 , DOI: 10.1016/j.pt.2020.05.012
Calvin Hon 1 , Kai Matuschewski 1
Affiliation  

Naturally acquired anti-Plasmodium falciparum immunity protects first and foremost against severe disease. Raj et al. have established a tantalizing path towards an anti-disease vaccine by identifying glutamic acid-rich protein (GARP) antibodies as signatures of protection against severe malaria in Tanzanian children and demonstrating efficacy in blood cultures and monkey trials.



中文翻译:

根据GARP的疟疾:抗疾病疫苗接种的新途径。

天然获得的抗恶性疟原虫免疫力首先保护免受严重疾病的侵害。拉杰。通过鉴定富含谷氨酸的蛋白(GARP)抗体作为坦桑尼亚儿童预防严重疟疾的标志,并证明了其在血液培养和猴子试验中的功效,已为诱人的抗疾病疫苗建立了诱人的途径。

更新日期:2020-07-15
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